人血清γ-球蛋白金属络合物诱导早期白细胞介素-1β的产生。

Production of early IL-1β induced by human serum γ-globulin metal complexes.

作者信息

Cheknev S B, Efremova I E, Piskovskaya L S, Yushkovets E N, Babajanz A A

机构信息

Laboratory of Cell-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health and Social Development of Russia, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2013 Jan;154(3):343-5. doi: 10.1007/s10517-013-1946-2.

DOI:10.1007/s10517-013-1946-2

PMID:23484196

Abstract

Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes formed by them with human serum γ-globulin induce the production of early (24-h incubation) IL-1β by human blood cells. The protein modified by Zn cations 1.2 times more actively (p<0.01) induced early IL-1β than the control γ-globulin, while γ-globulin metal complex with copper was 1.4 times less active (p<0.1) than the control protein. The regularities of induction changed over the course of 48-h incubation: zinc cations chelated by γ-globulin fraction protein reduced, while copper cations stimulated the realization of the protein induction potential in the metal complex.

摘要

血浆γ-球蛋白组分蛋白、铜和锌阳离子以及它们与人类血清γ-球蛋白形成的金属络合物可诱导人类血细胞产生早期（24小时孵育）白细胞介素-1β。经锌阳离子修饰的蛋白诱导早期白细胞介素-1β的活性比对照γ-球蛋白高1.2倍（p<0.01），而与铜形成的γ-球蛋白金属络合物的活性比对照蛋白低1.4倍（p<0.1）。在48小时孵育过程中，诱导规律发生了变化：γ-球蛋白组分蛋白螯合的锌阳离子减少，而铜阳离子则刺激了金属络合物中蛋白诱导潜力的实现。