Cheknev S B, Efremova I E, Apresova M A, Babajantz A A
Laboratory of Cell-to-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2013 Apr;154(6):758-61. doi: 10.1007/s10517-013-2049-9.
Plasma γ-globulin fraction proteins, copper and zinc cations, and metal complexes of these cations and human serum γ-globulin induce the production of TNF-α by human blood cells. The protein modified by zinc cations is by 1.4-1.7 times more potent (p<0.001-0.01) than control γ-globulin in inducing the production of TNF-α, while metal complex formed by γ-globulin and copper is by 1.9-2.2 times more potent that the control protein (p<0.001). Under conditions of experimental induction, TNF-α is produced as a typical early response cytokine. During long-term incubation, copper cations lose the ability to induce TNF-α production, while in combination with γ-globulin these cations produce a synergistic effect with the control protein.
血浆γ-球蛋白组分蛋白、铜和锌阳离子以及这些阳离子与人类血清γ-球蛋白的金属络合物可诱导人类血细胞产生肿瘤坏死因子-α（TNF-α）。锌阳离子修饰的蛋白在诱导TNF-α产生方面比对照γ-球蛋白强1.4至1.7倍（p<0.001至0.01），而γ-球蛋白与铜形成的金属络合物比对照蛋白强1.9至2.2倍（p<0.001）。在实验诱导条件下，TNF-α作为典型的早期反应细胞因子产生。在长期孵育过程中，铜阳离子失去诱导TNF-α产生的能力，而与γ-球蛋白结合时，这些阳离子与对照蛋白产生协同效应。
