血管紧张素原基因M235T多态性与子痫前期的基因表型分析
Genophenotypic analysis of angiotensinogen gene M235T polymorphism and preeclampsia.
作者信息
Radkov O V, Kalinkin M N, Zavarin V V
机构信息
Tver' State Medical Academy, Ministry of Health Care and Social Development of the Russian Federation, Russia.
出版信息
Bull Exp Biol Med. 2013 Jan;154(3):354-6. doi: 10.1007/s10517-013-1949-z.
We studied phenotypes of the circulating renin-angiotensin-aldosterone system and circadian BP during preeclampsia depending on polymorphism of angiotensinogen gene M235T. The TT genotype or T allele of angiotensinogen M235T gene polymorphism is associated with the risk of preeclampsia. Plasma renin activity significantly decreases under conditions of preeclampsia. The TT genotype of angiotensin M235T gene polymorphism is associated with highest renin activity and highest 24-h diastolic BP in comparison with MT and MM genotypes in patients with preeclampsia. Plasma aldosterone level is lower in patients with preeclampsia, but this is not related to angiotensinogen M235T gene polymorphism.
我们根据血管紧张素原基因M235T的多态性，研究了子痫前期患者循环肾素-血管紧张素-醛固酮系统的表型及昼夜血压。血管紧张素原M235T基因多态性的TT基因型或T等位基因与子痫前期风险相关。子痫前期时血浆肾素活性显著降低。与子痫前期患者的MT和MM基因型相比，血管紧张素M235T基因多态性的TT基因型与最高肾素活性及最高24小时舒张压相关。子痫前期患者的血浆醛固酮水平较低，但这与血管紧张素原M235T基因多态性无关。
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