大自然的恩赐——从海洋中发现药物。
Nature's bounty - drug discovery from the sea.
机构信息
The University of Mississippi, Department of Pharmacognosy, School of Pharmacy, University, MS 38677, USA +1 662 915 5730 ; +1 662 915 6975 ;
出版信息
Expert Opin Drug Discov. 2007 Nov;2(11):1505-22. doi: 10.1517/17460441.2.11.1505.
With ∼ 40 years of research completed after the development of self-contained underwater breathing apparatus, drug discovery opportunities in the sea are still too numerous to count. Since the FDA approval of the direct-from-the-sea calcium channel blocker ziconotide, marine natural products have been validated as a source for new medicines. However, the demand for natural products is extremely high due to the development of high-throughput assays and this bottleneck has created the need for an intense focus on increasing the rate of isolating and elucidating the structures of new bioactive secondary metabolites. In addition to highlighting the drug discovery potential of the marine environment, this review discusses several of the pressing needs to increase the rate of drug discovery in marine natural products, and describes some of the work and new technologies that are contributing in this regard.
在自主式水下呼吸器开发后完成了大约 40 年的研究，海洋中的药物发现机会仍然数不胜数。自 FDA 批准直接从海洋中提取的钙通道阻滞剂扎考昔定以来，海洋天然产物已被证实是新药的来源。然而，由于高通量检测方法的发展，对天然产物的需求极高，这一瓶颈促使人们需要集中精力提高分离和阐明新生物活性次生代谢产物结构的速度。本文除了强调海洋环境的药物发现潜力外，还讨论了提高海洋天然产物药物发现速度的一些紧迫需求，并介绍了一些在这方面做出贡献的工作和新技术。
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