Hayes H M, Tarone R E, Casey H W, Huxsoll D L
Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
J Natl Cancer Inst. 1990 Jun 20;82(12):1042-6. doi: 10.1093/jnci/82.12.1042.
During the Vietnam War, US military working dogs served with their companion dog handlers in close proximity, sharing common exposures to war-related activity, many zoonotic infectious agents, chemical pesticides, phenoxy herbicides, and extensive use of therapeutic drugs. To gain insight into the effects of the Vietnam experience, we investigated the occurrence of neoplasms in military working dogs based on standard necropsy examination by the Armed Forces Institute of Pathology. We observed that these dogs experienced significant elevated risks for testicular seminoma and, independently, testicular dysfunction. Experimental evidence shows testicular dysfunction and impaired spermatogenesis in laboratory animals exposed to phenoxy herbicides, dioxin, or tetracycline, and antibiotic used extensively in military working dogs in Vietnam. Because an unexplained significant decrease in sperm quality in Vietnam veterans has been observed by the Centers for Disease Control, further research is warranted if we are to clarify military service in Vietnam as a risk factor for testicular dysfunction. The testis should be made a priority site in the study of Vietnam experience-related cancers.
在越南战争期间，美国军犬与其训导员密切合作，共同经历与战争相关的活动、接触多种人畜共患传染病原体、化学杀虫剂、苯氧基除草剂，并大量使用治疗药物。为深入了解越战经历的影响，我们依据武装部队病理研究所的标准尸检，调查了军犬肿瘤的发生情况。我们发现这些犬患睾丸精原细胞瘤的风险显著升高，且独立出现睾丸功能障碍。实验证据表明，接触苯氧基除草剂、二恶英或四环素（越南军犬广泛使用的抗生素）的实验动物会出现睾丸功能障碍和精子发生受损。由于美国疾病控制中心观察到越战退伍军人的精子质量出现了无法解释的显著下降，若要明确越战服役是睾丸功能障碍的风险因素，就需要进一步研究。在研究与越战经历相关的癌症时，睾丸应作为重点研究部位。
