Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA.
J Am Chem Soc. 2013 Mar 27;135(12):4648-51. doi: 10.1021/ja400300g. Epub 2013 Mar 13.
This communication describes a mild copper-mediated fluorination of aryl stannanes and aryl trifluoroborates with N-fluoro-2,4,6-trimethylpyridinium triflate. This protocol demonstrates broad substrate scope and functional group tolerance, and does not require the use of any noble metal additives. The reaction is proposed to proceed via an arylcopper(III) fluoride intermediate.
本通讯描述了 N-氟-2,4,6-三甲基吡啶三氟甲磺酸酯介导的芳基锡烷和芳基三氟硼酸盐的温和氟化反应。该方案表现出广泛的底物范围和官能团容忍性，并且不需要使用任何贵金属添加剂。该反应被认为是通过芳基三氟甲磺酸亚铜氟化物中间体进行的。
