Wessex Blood and Marrow Transplantation Programme, Department of Haematology, Southampton University Hospitals Trust, SO16 6YD, UK.
J Clin Virol. 2013 Jun;57(2):165-8. doi: 10.1016/j.jcv.2013.02.003. Epub 2013 Feb 26.
We describe a rare case of fatal mumps encephalomyelitis occurring in 19-year old male following matched unrelated donor peripheral blood haematopoietic stem cell transplantation (HSCT). The indication for HSCT was for an undefined form of severe combined immunodeficiency (SCID). Molecular typing of the mumps viral RNA isolated from neural tissue indicated that the infection was acquired at the time of a mumps outbreak in England and Wales that occurred between 2004 and 2006. This case highlights the importance of considering mumps in the differential diagnosis of central nervous system infection in highly immunosuppressed patients.
我们描述了一例罕见的致命流行性腮腺炎脑炎病例，发生在一名 19 岁男性，他在接受匹配的无关供体外周血造血干细胞移植（HSCT）后。HSCT 的适应证是一种未明的严重联合免疫缺陷（SCID）。从神经组织中分离出的腮腺炎病毒 RNA 的分子分型表明，感染发生在 2004 年至 2006 年期间在英国和威尔士发生的腮腺炎暴发期间。该病例强调了在高度免疫抑制患者的中枢神经系统感染鉴别诊断中考虑腮腺炎的重要性。
