Institut de Mécanique des Fluides de Toulouse, Université de Toulouse, INPT, UPS, IMFT, Toulouse, France.
J Cereb Blood Flow Metab. 2013 May;33(5):669-72. doi: 10.1038/jcbfm.2013.39. Epub 2013 Mar 13.
Cerebral blood flow (CBF) is the most common parameter for the quantification of brain's function. Literature data indicate a widespread dispersion of values that might be related to some differences in the measurement conditions that are not properly taken into account in CBF evaluation. Using recent high-resolution imaging of the complete cortical microvasculature of primate brain, we perform extensive numerical evaluation of the cerebral perfusion. We show that blood perfusion associated with intravascular tracers should be normalized by the surface of the voxel rather than by its volume and we consistently test this result on the available literature data.
脑血流（CBF）是量化大脑功能最常用的参数。文献数据表明，其值存在广泛的分散性，这可能与 CBF 评估中未适当考虑的一些测量条件差异有关。利用最近对灵长类动物大脑完整皮质微血管的高分辨率成像，我们对脑灌注进行了广泛的数值评估。我们表明，与血管内示踪剂相关的血液灌注应该通过体素的表面积而不是体积来归一化，并且我们在现有的文献数据上一致地测试了这一结果。
