通过串联偶联-异构化-缩合反应构建吡咯并[1,2-b]哒嗪的新方法。
A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling-isomerization-condensation reaction.
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, P.R. China.
出版信息
Org Biomol Chem. 2013 Apr 28;11(16):2574-7. doi: 10.1039/c3ob40157j.
PMID:23487245
Abstract
A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.
摘要
一种新型 Pd/Cu 催化的串联反应，用于从易得的（杂）芳基炔丙醇和 1-氨基-2-溴代吡咯出发合成功能化的吡咯并[1,2-b]哒嗪。该级联过程涉及 Sonogashira 交叉偶联反应、异构化和分子内缩合。
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