State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, P.R. China.
Org Biomol Chem. 2013 Apr 28;11(16):2574-7. doi: 10.1039/c3ob40157j.
A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.
一种新型 Pd/Cu 催化的串联反应，用于从易得的（杂）芳基炔丙醇和 1-氨基-2-溴代吡咯出发合成功能化的吡咯并[1,2-b]哒嗪。该级联过程涉及 Sonogashira 交叉偶联反应、异构化和分子内缩合。
