钯（0）催化末端炔烃与烯丙醇的直接脱水偶联反应，以获得 1,4-烯炔。
A Pd(0)-catalyzed direct dehydrative coupling of terminal alkynes with allylic alcohols to access 1,4-enynes.
机构信息
Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
J Am Chem Soc. 2013 Aug 28;135(34):12536-9. doi: 10.1021/ja406025p. Epub 2013 Aug 19.
PMID:23947634
Abstract
A direct dehydrative coupling of terminal alkynes with allylic alcohols catalyzed by Pd(PPh3)4 with an N,P-ligand assisted by Ti(OiPr)4 has been developed. The coupling reaction tolerates various functional groups, providing a valuable synthetic tool to access 1,4-enynes.
摘要
Pd(PPh3)4 与 N,P-配体协同作用，Ti(OiPr)4 辅助催化末端炔烃与烯丙醇的直接脱水偶联反应已经被开发出来。该偶联反应能容忍各种官能团，为合成 1,4-烯炔提供了一种很有价值的工具。
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