• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

钯（0）催化末端炔烃与烯丙醇的直接脱水偶联反应，以获得 1,4-烯炔。

A Pd(0)-catalyzed direct dehydrative coupling of terminal alkynes with allylic alcohols to access 1,4-enynes.

机构信息

Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

出版信息

J Am Chem Soc. 2013 Aug 28;135(34):12536-9. doi: 10.1021/ja406025p. Epub 2013 Aug 19.

DOI:10.1021/ja406025p
PMID:23947634
Abstract

A direct dehydrative coupling of terminal alkynes with allylic alcohols catalyzed by Pd(PPh3)4 with an N,P-ligand assisted by Ti(OiPr)4 has been developed. The coupling reaction tolerates various functional groups, providing a valuable synthetic tool to access 1,4-enynes.

摘要

Pd(PPh3)4 与 N,P-配体协同作用，Ti(OiPr)4 辅助催化末端炔烃与烯丙醇的直接脱水偶联反应已经被开发出来。该偶联反应能容忍各种官能团，为合成 1,4-烯炔提供了一种很有价值的工具。

相似文献

1
A Pd(0)-catalyzed direct dehydrative coupling of terminal alkynes with allylic alcohols to access 1,4-enynes.钯（0）催化末端炔烃与烯丙醇的直接脱水偶联反应，以获得 1,4-烯炔。
J Am Chem Soc. 2013 Aug 28;135(34):12536-9. doi: 10.1021/ja406025p. Epub 2013 Aug 19.
2
Palladium-catalyzed cross-coupling of electron-poor terminal alkynes with arylboronic acids under ligand-free and aerobic conditions.钯催化的缺电子末端炔烃与芳基硼酸在无配体和有氧条件下的交叉偶联反应。
J Org Chem. 2010 Aug 20;75(16):5635-42. doi: 10.1021/jo101063p.
3
A cooperative copper- and palladium-catalyzed three-component coupling of benzynes, allylic epoxides, and terminal alkynes.一种铜和钯协同催化的苯炔、烯丙基环氧化物和末端炔烃的三组分偶联反应。
Angew Chem Int Ed Engl. 2009;48(2):391-4. doi: 10.1002/anie.200804873.
4
Palladium-catalyzed three-component coupling of arynes with allylic acetates or halides and terminal alkynes promoted by cuprous iodide.钯催化的芳炔与烯丙基乙酸酯或卤化物以及由碘化亚铜促进的末端炔烃的三组分偶联反应。
Chem Commun (Camb). 2008 May 14(18):2158-60. doi: 10.1039/b800118a. Epub 2008 Mar 3.
5
Nickel-catalyzed enantioselective alkylative coupling of alkynes and aldehydes: synthesis of chiral allylic alcohols with tetrasubstituted olefins.镍催化的炔烃与醛的对映选择性烷基化偶联反应：合成具有四取代烯烃的手性烯丙醇
J Am Chem Soc. 2008 Oct 29;130(43):14052-3. doi: 10.1021/ja805296k. Epub 2008 Oct 4.
6
Pd-catalyzed three-component coupling of N-tosylhydrazone, terminal alkyne, and aryl halide.钯催化的 N-对甲苯磺酰腙、末端炔烃和芳基卤化物的三组分偶联反应。
J Am Chem Soc. 2010 Oct 6;132(39):13590-1. doi: 10.1021/ja105762n.
7
Palladium-based catalytic systems for the synthesis of conjugated enynes by sonogashira reactions and related alkynylations.用于通过Sonogashira反应及相关炔基化反应合成共轭烯炔的钯基催化体系。
Angew Chem Int Ed Engl. 2007;46(6):834-71. doi: 10.1002/anie.200602761.
8
Dehydrative cross-coupling reactions of allylic alcohols with olefins.烯丙醇与烯烃的脱水交叉偶联反应。
Chemistry. 2014 Aug 25;20(35):10905-9. doi: 10.1002/chem.201404026. Epub 2014 Aug 11.
9
Palladium-catalyzed synthesis of indene derivatives via propargylic carbonates with in situ generated organozinc compounds.钯催化通过碳酸炔丙酯与原位生成的有机锌化合物合成茚衍生物。
Org Biomol Chem. 2008 Mar 21;6(6):1040-5. doi: 10.1039/b719957k. Epub 2008 Feb 12.
10
Pd-catalyzed asymmetric allylic alkylation of pyrazol-5-ones with allylic alcohols: the role of the chiral phosphoric acid in C-O bond cleavage and stereocontrol.钯催化吡唑-5-酮与烯丙醇的不对称烯丙基烷基化反应：手性磷酸在 C-O 键断裂和立体控制中的作用。
J Am Chem Soc. 2013 Jun 26;135(25):9255-8. doi: 10.1021/ja402740q. Epub 2013 Jun 14.

引用本文的文献

1
Selectivity switch via tuning surface static electric field in photocatalytic alcohol conversion.通过调节光催化醇转化中的表面静电场实现选择性切换。
Innovation (Camb). 2024 Jun 17;5(5):100659. doi: 10.1016/j.xinn.2024.100659. eCollection 2024 Sep 9.
2
Iridium-catalyzed enantioselective alkynylation and kinetic resolution of alkyl allylic alcohols.铱催化的对映选择性炔基化反应及烷基烯丙醇的动力学拆分
Chem Sci. 2022 Nov 1;13(46):13914-13921. doi: 10.1039/d2sc04892b. eCollection 2022 Nov 30.
3
Rhodium-catalyzed asymmetric hydroamination and hydroindolation of keto-vinylidenecyclopropanes.
铑催化的酮基亚乙烯基环丙烷的不对称氢胺化反应和氢吲哚化反应。
Chem Sci. 2018 May 11;9(22):5074-5081. doi: 10.1039/c8sc01595c. eCollection 2018 Jun 14.
4
Dual nickel and Lewis acid catalysis for cross-electrophile coupling: the allylation of aryl halides with allylic alcohols.双镍和路易斯酸催化的交叉亲电偶联反应：芳基卤化物与烯丙醇的烯丙基化反应
Chem Sci. 2017 Nov 6;9(3):640-645. doi: 10.1039/c7sc03140h. eCollection 2018 Jan 21.
5
Iminophosphanes: Synthesis, Rhodium Complexes, and Ruthenium(II)-Catalyzed Hydration of Nitriles.亚氨基膦烷：合成、铑配合物以及钌（II）催化的腈水合反应
Organometallics. 2017 Mar 13;36(5):1079-1090. doi: 10.1021/acs.organomet.7b00057. Epub 2017 Feb 16.
6
Palladium/N-heterocyclic carbene catalysed regio and diastereoselective reaction of ketones with allyl reagents via inner-sphere mechanism.钯/氮杂环卡宾催化酮与烯丙基试剂的区域和立体选择性反应通过内球机制。
Nat Commun. 2016 Jun 10;7:11806. doi: 10.1038/ncomms11806.