由炔丙醇-烯酮异构化开启的偶联-异构化-偶联序列。
Coupling-isomerization-coupling sequences switched on by propargyl alcohol-enone-isomerization.
作者信息
Braun Roland U, Müller Thomas J J
机构信息
Organisch-Chemisches Institut der Ruprecht-Karls- Universität Heidelberg, Im Neuenheimer Feld 270, Heidelberg, Germany.
出版信息
Mol Divers. 2003;6(3-4):251-9. doi: 10.1023/b:modi.0000006782.32899.94.
The coupling-isomerization-reaction (CIR) of an electron-deficient halide 1 with 1-(p-bromo phenyl) propyne-1-ol (2) leads to an in-situ activation of the carbon-bromine bond towards oxidative addition and has been elaborated to a consecutive CIR-coupling sequence where subsequent palladium catalyzed coupling reactions such as Sonogashira, CIR, Heck, or Suzuki reactions allow a rapid construction of more complex frameworks in a one-pot reaction and in moderate to good yields.
缺电子卤化物1与1-（对溴苯基）丙炔-1-醇（2）的偶联-异构化反应（CIR）导致碳-溴键原位活化以进行氧化加成，并且已发展为连续的CIR-偶联序列，其中随后的钯催化偶联反应，如Sonogashira反应、CIR反应、Heck反应或Suzuki反应，允许在一锅反应中以中等到良好的产率快速构建更复杂的骨架。
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