Mak-Kregar S, Hilgers F J, Baris G, Schouwenburg P F, Hart G A
Department of Head and Neck Surgery, The Netherlands Cancer Institute, Amsterdam.
Laryngoscope. 1990 Jun;100(6):634-8. doi: 10.1288/00005537-199006000-00015.
Between 1966 and 1985, 92 patients with local or locoregional tonsillar carcinoma were treated in the Netherlands Cancer Institute. Treatment consisted of radiotherapy in 79 patients, combination of surgery and postoperative radiotherapy in 10 patients, and surgery alone in 3 patients. The 5-year crude survival rate was 43% and the disease-free interval 57%. Patients were classified according to the UICC 1982 and the UICC 1987/AJCC 1988 criteria. The changes in the lymph node classification proposed in UICC 1987 lead to inversion in sizes of N1 and N2 groups, and of stages III and IV. The most important prognostic factor for disease-free interval is T stage (P = .03). Prognosis is significantly worse in stage IV (UICC 1982) compared to stages I to III (41% vs. 65%, respectively, P = .03). Crude survival is lower in males (P = .031) and in patients who smoked (P = .019).
1966年至1985年间，荷兰癌症研究所对92例局部或区域淋巴结扁桃体癌患者进行了治疗。79例患者接受了放射治疗，10例患者接受了手术及术后放射治疗的联合治疗，3例患者仅接受了手术治疗。5年粗生存率为43%，无病间期为57%。患者根据国际抗癌联盟（UICC）1982年及UICC 1987年/美国癌症联合委员会（AJCC）1988年标准进行分类。UICC 1987年提出的淋巴结分类变化导致N1和N2组以及Ⅲ期和Ⅳ期的大小倒置。无病间期最重要的预后因素是T分期（P = 0.03）。与Ⅰ至Ⅲ期相比，Ⅳ期（UICC 1982）的预后明显更差（分别为41%和65%，P = 0.03）。男性患者（P = 0.031）和吸烟患者（P = 0.019）的粗生存率较低。
