脑缺血后的神经保护。
Neuroprotection after cerebral ischemia.
机构信息
Neuroscience Institute, Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA, USA.
出版信息
Ann N Y Acad Sci. 2013 Mar;1278:25-32. doi: 10.1111/nyas.12087.
Abstract
Cerebral ischemia, a focal or global insufficiency of blood flow to the brain, can arise through multiple mechanisms, including thrombosis and arterial hemorrhage. Ischemia is a major driver of stroke, one of the leading causes of morbidity and mortality worldwide. While the general etiology of cerebral ischemia and stroke has been known for some time, the conditions have only recently been considered treatable. This report describes current research in this field seeking to fully understand the pathomechanisms underlying stroke; to characterize the brain's intrinsic injury, survival, and repair mechanisms; to identify putative drug targets as well as cell-based therapies; and to optimize the delivery of therapeutic agents to the damaged cerebral tissue.
摘要
脑缺血是指大脑的局部或整体血液供应不足，其可通过多种机制引起，包括血栓形成和动脉出血。脑缺血是中风的主要驱动因素之一，也是全球发病率和死亡率的主要原因之一。尽管人们已经了解脑缺血和中风的一般病因一段时间了，但这些疾病直到最近才被认为是可以治疗的。本报告介绍了目前在该领域的研究，旨在全面了解中风的病理机制；描述大脑的内在损伤、存活和修复机制；确定潜在的药物靶点和基于细胞的治疗方法；并优化治疗药物向受损脑组织的输送。
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