Massachusetts Institute of Technology, Harvard-MIT Division of Health Sciences and Technology, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA +1 617 768 8395 ; +1 617 768 8477 ;
Expert Opin Drug Discov. 2007 Dec;2(12):1653-68. doi: 10.1517/17460441.2.12.1653.
Micro- and nanoscale technologies are emerging as powerful enabling tools for tissue engineering and drug discovery. In tissue engineering, micro- and nanotechnologies can be used to fabricate biomimetic scaffolds with increased complexity and vascularization. Furthermore, these technologies can be used to control the cellular microenvironment (i.e., cell-cell, cell-matrix and cell-soluble factor interactions) in a reproducible manner and with high temporal and spatial resolution. In drug discovery, miniaturized platforms based on micro- and nanotechnology can be used to precisely control the fluid flow, enable high-throughput screening, and minimize sample or reagent volumes. In addition, these systems enhance reproducibility and significantly reduce reaction times. This paper reviews the recent developments in the field of micro- and nanoscale technology and gives examples of their tissue engineering and drug discovery applications.
微纳技术正在成为组织工程和药物发现的强大工具。在组织工程中，微纳技术可用于制造具有更高复杂性和血管化的仿生支架。此外，这些技术可以用于以可重复的方式和高时间和空间分辨率控制细胞微环境（即细胞-细胞、细胞-基质和细胞可溶性因子相互作用）。在药物发现中，基于微纳技术的小型化平台可用于精确控制流体流动，实现高通量筛选，并最小化样品或试剂体积。此外，这些系统提高了重现性并大大缩短了反应时间。本文综述了微纳技术领域的最新进展，并举例说明了它们在组织工程和药物发现中的应用。
