* Department of Veterinary Science and Microbiology , Tucson, Arizona , USA.
Med Mycol. 2013 Oct;51(7):747-54. doi: 10.3109/13693786.2013.770610. Epub 2013 Mar 14.
Nikkomycin Z (NikZ) is a chitin synthase inhibitor with antifungal efficacy against Coccidioides spp. and other endemic fungi. Dogs suffer a rate and range of natural coccidioidomycosis similar to humans and were considered an excellent model for initially testing NikZ against naturally acquired disease. Twelve dogs with coccidioidal pneumonia that had been present for an average of three months were treated with 250 mg (5-15 kg) or 500 mg (> 15-30 kg) twice daily for 60 days. Nine dogs completed the course of treatment and seven dogs had improvement in disease based on radiographs, clinicopathological parameters, physical examination findings, and subjective assessment by owners; three dogs had resolution or near resolution of disease. Based on this small study, NikZ shows efficacy to treat naturally acquired coccidioidomycosis and merits further development for trials in humans.
尼可霉素 Z（NikZ）是一种几丁质合成酶抑制剂，具有抗球虫病和其他地方性真菌的功效。狗患有与人类相似的球虫病的比率和范围，并且被认为是最初针对天然获得性疾病测试 NikZ 的理想模型。12 只患有球虫性肺炎的狗，平均患病时间为 3 个月，接受了 250 毫克（5-15 公斤）或 500 毫克（> 15-30 公斤），每天两次，共 60 天。9 只狗完成了治疗疗程，根据 X 光片、临床病理参数、体检结果以及主人的主观评估，7 只狗的疾病有所改善；3 只狗的疾病得到缓解或接近缓解。基于这项小型研究，NikZ 显示出治疗天然获得性球虫病的疗效，值得进一步开发用于人类试验。
