安布罗霉素类似物在球孢子菌病小鼠模型中的疗效。
Efficacy of ambruticin analogs in a murine model of coccidioidomycosis.
作者信息
Shubitz Lisa F, Galgiani John N, Tian Zong-Qiang, Zhong Ziyang, Timmermans Pieter, Katz Leonard
机构信息
Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85723, USA.
出版信息
Antimicrob Agents Chemother. 2006 Oct;50(10):3467-9. doi: 10.1128/AAC.00670-06.
Abstract
Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.
摘要
安布罗霉素S是一种抗真菌环丙基吡喃酸，对小鼠球孢子菌感染显示出治疗效果。对该化合物的两种体外活性更高的类似物进行了抗致死性小鼠球孢子菌感染的测试。两者都提高了小鼠的存活率，高于对照组；其中一种导致感染几乎完全消除。
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