Department of Chemical Engineering, Pohang University of Science and Technology, San31 Hyoja-dong, Nam-Gu, Pohang, Gyeongbuk, 790-784, South Korea.
Anal Chem. 2013 Apr 16;85(8):4038-44. doi: 10.1021/ac303778j. Epub 2013 Mar 29.
A digital microfluidic system based on a direct electric charging and subsequent electrophoretic manipulation of droplets is made by simple fabrication at low cost. Digitally controlled two-dimensional droplet motions are realized by digital polarity control of an array of electrodes. By independent control of droplets and colorimetric detection, the coalescence and mixing of droplets is analyzed quantitatively. The gelation of sodium alginate and the crystallization of calcium carbonate by multiple droplet translations and coalescence and the actuation of glassy carbon beads are demonstrated to show the versatile manipulation capability of the proposed technology. Finally, we discuss the implications and potentials of the present technology.
一种基于直接电充电和随后对液滴进行电泳操作的数字微流控系统，通过低成本的简单制造得以实现。通过对电极阵列的数字极性控制，实现了数字控制的二维液滴运动。通过对液滴和比色检测的独立控制，实现了液滴的聚结和混合的定量分析。通过多次液滴平移和聚结以及玻璃碳珠的驱动，演示了海藻酸钠的胶凝和碳酸钙的结晶，展示了所提出技术的多功能操作能力。最后，我们讨论了当前技术的意义和潜力。
