Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Lung Cancer. 2013 Jun;80(3):256-62. doi: 10.1016/j.lungcan.2013.02.017. Epub 2013 Mar 13.
Tumor-associated macrophages (TAMs) can be abundantly present in numerous cancer types. Under influence of various stimuli in the tumor microenvironment TAMs develop into a tumor-inhibitory (M1) or tumor-promoting (M2) phenotype. Recently, the role of TAMs in tumor biology and their prognostic value in cancer has become a major topic of interest. In this review we will discuss the importance of TAMs in the pathogenesis and clinical outcome of lung cancer and mesothelioma patients. In addition, the potential of TAMs as therapeutic targets will be discussed.
肿瘤相关巨噬细胞（TAMs）在许多癌症类型中都大量存在。在肿瘤微环境的各种刺激下，TAMs 可向抑瘤（M1）或促瘤（M2）表型转化。最近，TAMs 在肿瘤生物学中的作用及其在癌症中的预后价值已成为研究的热点。在本综述中，我们将讨论 TAMs 在肺癌和间皮瘤患者发病机制和临床结局中的重要性。此外，还将讨论 TAMs 作为治疗靶点的潜力。
