犬肥大细胞瘤中纤维母细胞激活蛋白的表达及其与组织学分级、有丝分裂指数和Ki67表达的相关性
Expression of Fibroblast Activating Protein and Correlation with Histological Grade, Mitotic Index and Ki67 Expression in Canine Mast Cell Tumours.
作者信息
Giuliano A, Dos Santos Horta R, Constantino-Casas F, Hoather T, Dobson J
机构信息
University of Cambridge, Department of Veterinary Medicine, Madingley Road, Cambridge, UK.
Universidade Federal de Minas Gerais, Department of Veterinary Medicine and Surgery, Brazil.
出版信息
J Comp Pathol. 2017 Jan;156(1):14-20. doi: 10.1016/j.jcpa.2016.10.004. Epub 2016 Nov 24.
Fibroblast activating protein (FAP) is a membrane serine protease expressed by activated fibroblasts, particularly tumour associated fibroblasts (TAFs). FAP expression has not been reported in canine mast cell tumours (MCTs). The objective of this study was to evaluate the expression of FAP in TAFs and its correlation with histological grade, mitotic index and Ki67 expression in canine MCTs. FAP expression was evaluated by immunohistochemistry (IHC) in 30 canine MCTs. Twenty-eight (90%) of the MCTs expressed FAP in the stroma, 16 cases showed low to intermediate FAP score and 14 cases had a high FAP score. FAP was correlated positively with both Patnaik (P = 0.007) and Kiupel (P = 0.008) grading systems, mitotic index (P = 0.0008) and Ki67 expression (P = 0.009). High stromal FAP expression could be a potential negative prognostic factor in canine MCTs.
成纤维细胞激活蛋白（FAP）是一种由活化的成纤维细胞表达的膜丝氨酸蛋白酶，尤其是肿瘤相关成纤维细胞（TAF）。犬肥大细胞瘤（MCT）中尚未有FAP表达的报道。本研究的目的是评估TAF中FAP的表达及其与犬MCT组织学分级、有丝分裂指数和Ki67表达的相关性。通过免疫组织化学（IHC）对30例犬MCT进行FAP表达评估。28例（90%）MCT在基质中表达FAP，16例显示低至中度FAP评分，14例具有高FAP评分。FAP与帕特奈克（P = 0.007）和基佩尔（P = 0.008）分级系统、有丝分裂指数（P = 0.0008）和Ki67表达（P = 0.009）均呈正相关。基质FAP高表达可能是犬MCT的潜在不良预后因素。
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