Feurle G E
Gastroenterology. 1975 Jan;68(1):1-7.
The interrelationship of the effects of antacids and of rising intragastric pH on serum gastrin levels was examined by comparing the effect of three antacids (Mg(OH)2Al(OH)3, and CaCO3), and their nonbuffering chloride compounds (MgCl2, AlCl3, and CaCl2), on serum gastrin and intragastric pH in duodenal ulcer patients. In the case of calcium, the effect of CaCl2 with a pH of 10, and in another group, CaCl2 with a pH of 2, was studied. In the case of magnesium, a control group was also investigated. In another group, the effect of a nonionized suspension (BaSO4) was studied in order to assess the contribution of intragastric volume. Serum gastrin was determined radioimmunologically, and pH measurements were performed in vitro using a glass electrode. Serum gastrin concentrations rose significantly whenever intragastric pH was raised. Serum gastrin also rose after MgCl2, AlCl3, and CaCl2 with a pH of 2, when intragastric pH was not significantly altered. This rise, however, was significantly smaller than after administration of the antacids, except in the MgCl2-Mg(OH)2 and in the CaCl2 pH 10-CaCO3 groups. No significant rise of serum gastrin levels was observed after BaSO4. In nonulcer subjects, gastrin response was smaller than in the duodenal ulcer patients. The results suggest that administration of nonbuffering Mg-, Al-, and Ca-chlorides leads to elevated serum gastrin levels in duodenal ulcer patients; rising intragastric pH, however, exerts an additional serum gastrin response.
通过比较三种抗酸剂（氢氧化镁、氢氧化铝和碳酸钙）及其非缓冲性氯化物化合物（氯化镁、氯化铝和氯化钙）对十二指肠溃疡患者血清胃泌素和胃内pH值的影响，研究了抗酸剂的作用与胃内pH值升高对血清胃泌素水平的相互关系。对于钙，研究了pH值为10的氯化钙以及另一组pH值为2的氯化钙的作用。对于镁，还研究了一个对照组。在另一组中，研究了非离子悬浮液（硫酸钡）的作用，以评估胃内体积的影响。采用放射免疫法测定血清胃泌素，使用玻璃电极在体外进行pH值测量。每当胃内pH值升高时，血清胃泌素浓度显著升高。在胃内pH值未显著改变的情况下，pH值为2的氯化镁、氯化铝和氯化钙给药后血清胃泌素也会升高。然而，除了氯化镁 - 氢氧化镁组和pH值为10的氯化钙 - 碳酸钙组外，这种升高明显小于抗酸剂给药后的升高。硫酸钡给药后未观察到血清胃泌素水平显著升高。在非溃疡受试者中，胃泌素反应小于十二指肠溃疡患者。结果表明，给予非缓冲性镁、铝和钙的氯化物会导致十二指肠溃疡患者血清胃泌素水平升高；然而，胃内pH值升高会产生额外的血清胃泌素反应。
