Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Med Hypotheses. 2013 Jun;80(6):701-5. doi: 10.1016/j.mehy.2013.02.013. Epub 2013 Mar 13.
Sleep is important for maintenance of skeletal muscle health. Sleep debt can induce muscle atrophy by increasing glucocorticoids and decreasing testosterone, growth hormone and insulin-like growth factor-I. These hormonal alterations result in a highly proteolytic environment characterized by decreased protein synthesis and increased degradation. Given that sleep deprivation is increasingly prevalent in modern society, strategies to minimize or reverse its adverse effects need to be investigated. Resistance exercise has been suggested as an intervention that would benefit the muscle health. The practice of this type of exercise can increase the concentration of testosterone, growth hormone and insulin-like growth factor I and stimulate the protein synthesis through a key signaling molecule, mammalian target of rapamycin. Thus, we hypothesized that resistance exercise is an important non-pharmacological strategy to counteract deleterious effects of sleep debt on skeletal muscle.
睡眠对于维持骨骼肌健康很重要。睡眠债会通过增加糖皮质激素和减少睾丸酮、生长激素和胰岛素样生长因子-1 导致肌肉萎缩。这些激素的改变导致高度蛋白水解环境，其特征是蛋白质合成减少和降解增加。鉴于睡眠剥夺在现代社会中越来越普遍，需要研究最小化或逆转其不良影响的策略。阻力运动已被建议作为一种干预措施，有益于肌肉健康。这种运动类型的练习可以通过一种关键的信号分子——雷帕霉素哺乳动物靶蛋白来增加睾丸酮、生长激素和胰岛素样生长因子-1 的浓度，并刺激蛋白质合成。因此，我们假设阻力运动是一种重要的非药物策略，可以对抗睡眠债对骨骼肌的有害影响。
