Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, 43201 Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43007 Reus, Spain.
Nutrients. 2019 Apr 1;11(4):761. doi: 10.3390/nu11040761.
The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndromein the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = 0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = 0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.
本研究旨在评估与血清尿酸（SUA）浓度和 SUA 与肌酐比值相关的睡眠时间和睡眠变异性。这是对超重/肥胖和代谢综合征的 1842 名老年参与者（Prevención con Dieta Mediterránea）PREDIMED-Plus 试验的基线数据进行的横断面分析。通过加速计测量睡眠时间和睡眠变异性。拟合线性回归模型来检验上述关联。睡眠时间每增加 1 小时/晚，与 SUA 浓度呈负相关（β=0.07，p=0.047）。进一步调整白细胞后，这种关联减弱（p=0.050）。睡眠时间每增加 1 小时，与 SUA 与肌酐比值呈负相关（β=0.15，p=0.001）。本研究结果表明，睡眠时间较长与较低的 SUA 浓度和较低的 SUA 与肌酐比值相关。
