Salut Mental Parc Taulí, Corporació Sanitària Universitària Parc Taulí, Sabadell, Institut Universitari Parc Taulí - UAB (IUFPT-UAB), España.
Grupo de Neurociencias [Institut Recerca Biomèdica Bellvitge] IDIBELL, Unidad clínica e investigación de trastornos afectivos, Servicio de Psiquiatría, Hospital Universitari de Bellvitge-ICS, L'Hospitalet de Llobregat, Universitat de Barcelona, Barcelona, España.
Rev Psiquiatr Salud Ment. 2014 Jan-Mar;7(1):42-7. doi: 10.1016/j.rpsm.2013.01.002. Epub 2013 Mar 11.
To determine the influence of propofol and thiopental as anesthetics in electroconvulsive therapy (ECT), as regards, seizure duration, electrical charge, clinical efficacy, cardiovascular profile, and presence of adverse cognitive effects.
A retrospective design including 127 patients who received bilateral ECT for the treatment of a major depressive episode.
The mean seizure duration in the propofol group was significantly shorter than in the thiopental group (21.23±6.09 versus 28.24±6.6 7s, P<.001). The mean stimulus charge was 348.22 mC in the propofol group, and 238 mC in the thiopental group (P<.001). Propofol was associated with a lower increase in blood pressure. There were no differences between groups in treatment response or presence of adverse effects.
The anesthetic agent used in ECT might determine differences in parameters such as seizure duration or electrical charge. However, this does not seem to be translated into differences in clinical efficacy or the pattern of adverse effects observed.
确定丙泊酚和硫喷妥钠作为麻醉剂在电惊厥疗法（ECT）中的影响，涉及到癫痫持续时间、电刺激量、临床疗效、心血管状况以及认知不良反应的发生。
采用回顾性设计，纳入 127 例因治疗重度抑郁发作而接受双侧 ECT 的患者。
丙泊酚组的平均癫痫发作持续时间明显短于硫喷妥钠组（21.23±6.09 秒 vs. 28.24±6.67 秒，P<.001）。丙泊酚组的平均刺激电量为 348.22 mC，而硫喷妥钠组为 238 mC（P<.001）。丙泊酚与血压升高幅度降低相关。两组在治疗反应或不良反应的发生方面无差异。
ECT 中使用的麻醉剂可能会导致癫痫持续时间或电刺激量等参数的差异。然而，这似乎并没有转化为临床疗效或观察到的不良反应模式的差异。
