Medical Toxicology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2011 Jul;14(4):308-17.
Widespread use of herbal drugs because of their protective effects on different organs toxicity has been shown in many studies. These protective effects have been illustrated in the fields of nephrotoxicity, hepatotoxicity, viral hepatitis, cancer, in vitro fertilization, neurotoxicity, depression, lung diseases, prostate diseases etc. Silymarin has cytoprotection activities due to its antioxidant activity and radical scavenging. The possible known mechanisms of action of silymarin protection are blockade and adjustment of cell transporters, p-glycoprotein, estrogenic and nuclear receptors. Moreover, silymarin anti-inflammatory effects through reduction of TNF-α, protective effects on erythrocyte lysis and cisplatin-induced acute nephrotoxicity have been indicated in some studies. Silymarin has also inhibited apoptosis and follicular development in patients undergoing IVF. Basis on such data, silymarin can be served as a novel medication in complementary medicine.
由于草药对不同器官毒性的保护作用，它们在许多研究中被广泛使用。这些保护作用已在肾毒性、肝毒性、病毒性肝炎、癌症、体外受精、神经毒性、抑郁、肺部疾病、前列腺疾病等领域得到了说明。水飞蓟素具有抗氧化活性和自由基清除作用，具有细胞保护活性。水飞蓟素保护作用的可能已知作用机制是阻断和调节细胞转运蛋白、P-糖蛋白、雌激素和核受体。此外，一些研究表明，水飞蓟素具有抗炎作用，可通过降低 TNF-α，对红细胞溶解和顺铂诱导的急性肾毒性具有保护作用。水飞蓟素还抑制接受 IVF 的患者的细胞凋亡和卵泡发育。基于这些数据，水飞蓟素可以作为一种新型药物用于补充医学。
