Munksgaard E C, Freund M
Department of Dental Materials and Technology, Royal Dental College, Copenhagen, Denmark.
Scand J Dent Res. 1990 Jun;98(3):261-7. doi: 10.1111/j.1600-0722.1990.tb00971.x.
Di- and monomethacrylates hydrolyze to methacrylic acid and the alcohol part at neutral pH catalyzed by an unspecific esterase (hydrolase) and by enzymes in saliva. The rate constants of the enzymatic hydrolysis of various (di)methacrylates increase in the following order: HPMA less than BISGMA less than LAMA less than DECMA less than TEGDMA less than UEDMA less than DEGDMA. Esterase added to aqueous slurries of various powders made of polymerized BISGMA/TEGDMA-mixtures gave rise to liberation of methacrylic acid, presumably deriving from degradation of those of the dimethacrylates only bonded in the matrix by one end of the molecule. It was estimated that a TEGDMA-polymer will be hydrolyzed faster than a BISGMA-polymer. It is proposed that hydrolases in saliva increase the wear rate of composite resin fillings.
在中性pH值条件下，二甲基丙烯酸酯和单甲基丙烯酸酯会在非特异性酯酶（水解酶）和唾液中的酶催化下水解为甲基丙烯酸和醇部分。各种（二）甲基丙烯酸酯的酶促水解速率常数按以下顺序增加：HPMA＜BISGMA＜LAMA＜DECMA＜TEGDMA＜UEDMA＜DEGDMA。向由聚合的BISGMA/TEGDMA混合物制成的各种粉末的水性浆料中添加酯酶，会导致甲基丙烯酸的释放，推测这仅源于分子一端仅结合在基质中的二甲基丙烯酸酯的降解。据估计，TEGDMA聚合物比BISGMA聚合物水解得更快。有人提出，唾液中的水解酶会增加复合树脂填充物的磨损率。
