Freund M, Munksgaard E C
Department of Dental Materials & Technology, Royal Dental College, Copenhagen, Denmark.
Scand J Dent Res. 1990 Aug;98(4):351-5. doi: 10.1111/j.1600-0722.1990.tb00984.x.
The microhardness of the surfaces of BISGMA/TEGDMA-polymers decreased after treatment with pork liver esterase for 48 h in concentrations greater than or equal to 0.05 U/ml. This softening effect on BISGMA/TEGDMA-polymer surfaces was also shown as an increased wear rate of the polymers in the presence of esterase measured by a laboratory abrasion method. In this method, polymer cylinders were vigorously shaken in an aqueous slurry containing abrasive particles. The shaking was performed for 3 s followed by a rest period of either 100 or 200 s. This was repeated for 24 h. A greater mean loss of weight of the cylinders was measured when esterase was present in the slurry and the loss of weight increased significantly from 6.7% to 23.8% (P less than 0.001) when the rest period was increased from 100 s to 200 s. The results indicate that enzymatic hydrolytic activity in the mouth will contribute to a breakdown of composite resin fillings.
在浓度大于或等于0.05 U/ml的猪肝酯酶处理48小时后，双酚A缩水甘油醚甲基丙烯酸酯/三乙二醇二甲基丙烯酸酯聚合物（BISGMA/TEGDMA-聚合物）表面的显微硬度降低。在酯酶存在的情况下，通过实验室磨损方法测得的聚合物磨损率增加，这也表明了酯酶对BISGMA/TEGDMA-聚合物表面的这种软化作用。在该方法中，聚合物圆柱体在含有磨料颗粒的水性浆料中剧烈摇动。摇动持续3秒，随后是100或200秒的静止期。重复此操作24小时。当浆料中存在酯酶时，测得圆柱体的平均重量损失更大，并且当静止期从100秒增加到200秒时，重量损失从6.7%显著增加到23.8%（P小于0.001）。结果表明，口腔中的酶促水解活性将导致复合树脂填充物的分解。
