Genetic testing in couples undergoing assisted reproduction technique protocols.
作者信息
Stuppia Liborio, Gatta Valentina, Antonucci Ivana, Giuliani Rossella, Scioletti Anna Paola, Palka Giandomenico
机构信息
G. d' Annunzio University, Department of Biomedical Sciences, Via dei Vestini 35 66013, Chieti-Pescara, Italy +39 08713554137 ; +39 08713554135 ;
出版信息
Expert Opin Med Diagn. 2009 Sep;3(5):571-83. doi: 10.1517/17530050902970986. Epub 2009 Jul 29.
BACKGROUND
An increasing number of couples undergo assisted reproduction techniques (ART) to generate a child, with the risk of the transmission to the offspring of a genetic defect underlying the condition of infertility.
OBJECTIVE
To review the most common genetic causes of infertility and identify the appropriate genetic testing to be carried out to reduce the risk of genetic defect in the offspring.
METHOD
Review of the literature in the field.
RESULTS/CONCLUSION: Cytogenetic investigation and screening of the CFTR gene are the only genetics testing suggested in all the couples undergoing ART; other tests should be performed only in selected cases.
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