Centre for Clinical Research, University of Queensland, Brisbane, QLD, Australia.
Med J Aust. 2013 Mar 18;198(5):270-2. doi: 10.5694/mja12.11703.
To determine research priorities of infectious diseases physicians for clinician-initiated randomised controlled trials (RCTs).
DESIGN, SETTING AND PARTICIPANTS: Online survey of infectious diseases physicians in Australia and New Zealand.
Research priorities for, and perceived barriers to, clinician-initiated RCTs.
122/550 infectious diseases physicians (22%) responded to the survey. The five highest ranked proposals for clinician-initiated RCTs were in the areas of prosthetic joint infections, septic arthritis and osteomyelitis of native joints, Staphylococcus aureus bloodstream infections, diabetic foot infections and the treatment of serious multiresistant, gram-negative bacterial infections. Lack of funding was the most important perceived barrier to participation in clinician-initiated RCTs.
The research focus of infectious diseases physicians - optimal treatment of commonly encountered serious infections - highlights a lack of well conducted RCTs in this area.
确定传染病医生对临床医生发起的随机对照试验（RCT）的研究重点。
设计、地点和参与者：对澳大利亚和新西兰的传染病医生进行在线调查。
临床医生发起 RCT 的研究重点和感知障碍。
在 550 名传染病医生中，有 122 名（22%）对调查做出了回应。临床医生发起 RCT 的五个最高排名的提案分别在以下领域：人工关节感染、化脓性关节炎和原发性关节骨髓炎、金黄色葡萄球菌血流感染、糖尿病足感染和严重多药耐药革兰氏阴性菌感染的治疗。缺乏资金是参与临床医生发起的 RCT 的最重要的感知障碍。
传染病医生的研究重点是治疗常见的严重感染，这突出表明在该领域缺乏精心设计的 RCT。
