Department of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC), P,O, Box 5800, Maastricht, 6202 AZ, the Netherlands.
Allergy Asthma Clin Immunol. 2013 Mar 15;9(1):10. doi: 10.1186/1710-1492-9-10.
The aetiology of childhood asthma is complex. An early dysfunction in the immunological development of the innate immune system in combination with environmental factors possibly triggers asthma. CD14 and toll-like receptors are important components of the innate immune system. The aim of this systematic review was to obtain a better insight into the relation between CD14 and toll-like receptors and childhood asthma in Caucasians. We searched PubMed and EMBASE for relevant articles. In total, 44 articles were included. The quality of the selected studies was independently assessed by the first two authors using the Newcastle-Ottawa quality assessment scale. Toll-like receptor 2, toll-like receptor 6, toll-like receptor 9, and toll-like receptor 10 appear to have some association with childhood asthma in Caucasians. The evidence for a relation of CD14 with childhood asthma is limited. In conclusion, there is no convincing evidence yet for a role of CD14 and toll-like receptors in relation to childhood asthma. Future studies should include haplotype analysis and take environmental factors into account to further clarify the role of CD14 and toll-like receptors on childhood asthma.
儿童哮喘的病因复杂。先天免疫系统的免疫发育早期功能障碍与环境因素相结合可能引发哮喘。CD14 和 Toll 样受体是先天免疫系统的重要组成部分。本系统评价的目的是更好地了解 CD14 和 Toll 样受体与白种人儿童哮喘之间的关系。我们在 PubMed 和 EMBASE 上搜索了相关文章。总共纳入了 44 篇文章。前两位作者使用纽卡斯尔-渥太华质量评估量表独立评估了所选研究的质量。Toll 样受体 2、Toll 样受体 6、Toll 样受体 9 和 Toll 样受体 10 似乎与白种人儿童哮喘有关。CD14 与儿童哮喘的关系证据有限。总之，目前尚无令人信服的证据表明 CD14 和 Toll 样受体在儿童哮喘中起作用。未来的研究应包括单倍型分析，并考虑环境因素，以进一步阐明 CD14 和 Toll 样受体在儿童哮喘中的作用。
