转录调控及其在疾病中的异常调控。
Transcriptional regulation and its misregulation in disease.
机构信息
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
出版信息
Cell. 2013 Mar 14;152(6):1237-51. doi: 10.1016/j.cell.2013.02.014.
Abstract
The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.
摘要
在人类中，建立和维持特定细胞状态的基因表达程序受数千个转录因子、辅助因子和染色质调节剂控制。这些基因表达程序的失调可导致广泛的疾病。本文我们综述了在转录调控理解方面的最新进展，并讨论了这些进展如何为疾病中的转录失调提供新的见解。
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