基因调控通路中剪接的动态整合。
Dynamic integration of splicing within gene regulatory pathways.
机构信息
Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, ON M5S 1A8, Canada.
出版信息
Cell. 2013 Mar 14;152(6):1252-69. doi: 10.1016/j.cell.2013.02.034.
Abstract
Precursor mRNA splicing is one of the most highly regulated processes in metazoan species. In addition to generating vast repertoires of RNAs and proteins, splicing has a profound impact on other gene regulatory layers, including mRNA transcription, turnover, transport, and translation. Conversely, factors regulating chromatin and transcription complexes impact the splicing process. This extensive crosstalk between gene regulatory layers takes advantage of dynamic spatial, physical, and temporal organizational properties of the cell nucleus, and further emphasizes the importance of developing a multidimensional understanding of splicing control.
摘要
前体 mRNA 剪接是后生动物物种中受高度调控的过程之一。除了产生大量的 RNA 和蛋白质外，剪接对其他基因调控层（包括 mRNA 转录、周转、运输和翻译）有深远的影响。相反，调节染色质和转录复合物的因素会影响剪接过程。这种基因调控层之间的广泛串扰利用了细胞核的动态空间、物理和时间组织特性，进一步强调了多维理解剪接控制的重要性。
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