Batsakis J G, Bautina E
Dept of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Ann Otol Rhinol Laryngol. 1990 Jun;99(6 Pt 1):501-3. doi: 10.1177/000348949009900618.
Secondary neoplastic involvement of the major salivary glands, most often the parotid, can be from regional (supraclavicular) and distant (infraclavicular) primary neoplasms. Cutaneous squamous cell carcinomas and melanomas are the most frequent offenders, and their numbers dominate all statistics dealing with metastases to the salivary glands and their lymph nodes. Carcinomas of the lungs, breast, and kidneys are the most frequent infraclavicular neoplasms that metastasize to the major salivary glands, and they most often manifest a hematogenous dissemination. Supraclavicular primary disease metastasizes to the salivary glands and their lymph nodes via a more diverse manner: direct extension, lymphatic spread, or, less often, blood vascular transport.
大唾液腺的继发性肿瘤累及，最常见于腮腺，可源自区域（锁骨上）和远处（锁骨下）原发性肿瘤。皮肤鳞状细胞癌和黑色素瘤是最常见的病因，在所有关于唾液腺及其淋巴结转移的统计数据中，它们的数量占主导。肺癌、乳腺癌和肾癌是最常见的锁骨下肿瘤，可转移至大唾液腺，且它们最常表现为血行播散。锁骨上原发性疾病通过多种方式转移至唾液腺及其淋巴结：直接蔓延、淋巴扩散，或较少见的血管转移。
