Sato K, Niki E, Shimasaki H
Department of Reaction Chemistry, Faculty of Engineering, University of Tokyo, Japan.
Arch Biochem Biophys. 1990 Jun;279(2):402-5. doi: 10.1016/0003-9861(90)90508-v.
The oxidation of human low density lipoprotein (LDL) initiated by free radical initiator and its inhibition by vitamin E and water-soluble antioxidants have been studied. It was found that the kinetic chain length was considerably larger than 1, suggesting that LDL was oxidized by a free radical chain mechanism. Vitamin E acted as a lipophilic chain-breaking antioxidant. Water-soluble chain-breaking antioxidants such as ascorbic acid and uric acid suppressed the oxidation of LDL initiated by aqueous radicals but they could not scavenge lipophilic radicals within LDL to break the chain propagation. Ascorbic acid acted as a synergistic antioxidant in conjunction with vitamin E.
研究了自由基引发剂引发的人低密度脂蛋白（LDL）氧化以及维生素E和水溶性抗氧化剂对其的抑制作用。发现动力学链长远大于1，这表明LDL是通过自由基链机制被氧化的。维生素E作为亲脂性链断裂抗氧化剂。水溶性链断裂抗氧化剂如抗坏血酸和尿酸可抑制水相自由基引发的LDL氧化，但它们无法清除LDL内的亲脂性自由基以中断链传播。抗坏血酸与维生素E协同发挥抗氧化作用。
