Niki E, Noguchi N, Gotoh N
Research Center for Advanced Science and Technology, University of Tokyo, Japan.
J Nutr Sci Vitaminol (Tokyo). 1993;39 Suppl:S1-8. doi: 10.3177/jnsv.39.supplement_s1.
Oxidation of LDL induced by free radicals proceeds by a chain mechanism to give phosphatidylcholine hydroperoxides and cholesteryl ester hydroperoxides as the major primary products. In addition, apolipoprotein B100 is also oxidized. Various antioxidants suppress the oxidative modification of LDL. Water-soluble radical-scavenging antioxidants such as vitamin C and uric acid act as the first defense to suppress the chain initiation. Lipophilic radical-scavenging antioxidants in LDL such as vitamin E and ubiquinol scavenge radicals attacking from outside and also within the LDL. The overall importance and potency of antioxidants depend not only on chemical reactivity but also on the physical factors such as location and mobility at the microenvironment in LDL.
自由基诱导的低密度脂蛋白（LDL）氧化通过链式机制进行，产生氢过氧化磷脂酰胆碱和氢过氧化胆固醇酯作为主要的初级产物。此外，载脂蛋白B100也会被氧化。各种抗氧化剂可抑制LDL的氧化修饰。水溶性自由基清除抗氧化剂如维生素C和尿酸作为第一道防线抑制链引发。LDL中的亲脂性自由基清除抗氧化剂如维生素E和泛醇可清除从外部以及LDL内部攻击的自由基。抗氧化剂的总体重要性和效力不仅取决于化学反应性，还取决于诸如LDL微环境中的位置和流动性等物理因素。
