Institute of Materials Research and Engineering, Singapore Singapore Bioimaging Consortium, Singapore.
J Healthc Eng. 2013;4(1):23-45. doi: 10.1260/2040-2295.4.1.23.
This review focuses on MRI contrast agents for tumor diagnosis. Several types of low molecular weight Gd3+-based complexes and dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles have been used for clinical tumor diagnosis as longitudinal relaxation time (T1) and transverse relaxation time (T2) MRI contrast agents, respectively. To further improve the sensitivity of MRI, new types of chelates for T1 MRI contrast agents and combination of low molecular weight T1 MRI contrast agents with different types of carriers have been investigated. Different types of materials for forming secure coating layers of SPIO and novel superparamagnetic particles with higher relaxivity values have been explored. Various types of ligands were applied to improve the capability to target tumor for both T1 and T2 contrast agents. Furthermore, MRI contrast agents for detection of tumor metabolism were also pursued.
这篇综述专注于用于肿瘤诊断的 MRI 对比剂。几种类型的低分子量 Gd3+-基配合物和葡聚糖包覆的超顺磁性氧化铁（SPIO）纳米颗粒已分别被用作纵向弛豫时间（T1）和横向弛豫时间（T2）MRI 对比剂，用于临床肿瘤诊断。为了进一步提高 MRI 的灵敏度，已研究了用于 T1 MRI 对比剂的新型螯合物以及将低分子量 T1 MRI 对比剂与不同类型载体结合的方法。人们还探索了用于形成 SPIO 更稳定包覆层的各种类型的材料以及具有更高弛豫率值的新型超顺磁颗粒。应用了各种类型的配体来提高 T1 和 T2 对比剂对肿瘤靶向的能力。此外，还研究了用于检测肿瘤代谢的 MRI 对比剂。
