College of Chemistry, Beijing Normal University, Beijing 100875, China.
Nanoscale. 2012 Oct 21;4(20):6235-43. doi: 10.1039/c2nr31865b.
Magnetic resonance imaging (MRI) yields high spatially resolved contrast with anatomical details for diagnosis, deeper penetration depth and rapid 3D scanning. To improve imaging sensitivity, adding contrast agents accelerates the relaxation rate of water molecules, thereby greatly increasing the contrast between specific issues or organs of interest. Currently, the majority of T(1) contrast agents are paramagnetic molecular complexes, typically Gd(iii) chelates. Various nanoparticulate T(1) and T(1)/T(2) contrast agents have recently been investigated as novel agents possessing the advantages of both the T(1) contrast effect and nanostructural characteristics. In this minireview, we describe the recent progress of these inorganic nanoparticle-based MRI contrast agents. Specifically, we mainly report on Gd and Mn-based inorganic nanoparticles and ultrasmall iron oxide/ferrite nanoparticles.
磁共振成像（MRI）具有高空间分辨率对比度和解剖细节，可用于诊断，具有更深的穿透深度和快速的 3D 扫描。为了提高成像灵敏度，添加造影剂会加速水分子的弛豫率，从而大大增加特定问题或感兴趣器官之间的对比度。目前，大多数 T(1)造影剂是顺磁分子配合物，通常为 Gd(iii)螯合物。最近，人们研究了各种纳米颗粒 T(1)和 T(1)/T(2)造影剂作为新型造影剂，兼具 T(1)造影效果和纳米结构特性的优势。在这篇综述中，我们描述了这些基于无机纳米粒子的 MRI 造影剂的最新进展。具体而言，我们主要报告基于 Gd 和 Mn 的无机纳米粒子以及超小的氧化铁/铁氧体纳米粒子。
