Extermann Martine
Senior Adult Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA.
Interdiscip Top Gerontol. 2013;38:49-60. doi: 10.1159/000343621. Epub 2013 Jan 17.
As older patients present with an average of three comorbidities beside their cancer, geriatric oncology can provide unique clues to translational research in aging and cancer. We illustrate this approach with the example of the metabolic syndrome and cancer. Epidemiologic and clinical cohorts highlighted an association between the metabolic syndrome and a higher risk and worse prognosis of various cancers. In a bedside-to-bench transition, this led to an interest in analyzing the potential mechanisms underlying this association. At least ten potential mechanisms could be implicated, with the challenge of understanding which are the dominant ones in human patients. Bench-to-bedside studies are beginning to shed some light on that aspect, and some therapeutic trials are beginning to exploit the lessons learned.
由于老年患者除患癌症外平均还患有三种合并症，老年肿瘤学可为衰老与癌症的转化研究提供独特线索。我们以代谢综合征与癌症为例来说明这种方法。流行病学和临床队列研究突出了代谢综合征与多种癌症的较高风险及较差预后之间的关联。在从床边到实验室的转化过程中，这引发了人们对分析这种关联背后潜在机制的兴趣。可能涉及至少十种潜在机制，而难点在于了解哪些是人类患者中的主要机制。从实验室到床边的研究已开始在这方面有所启发，一些治疗试验也已开始借鉴所学到的经验。
