Department of Medical Science, Division of Health Science, University of Guanajuato, Campus León, Guanajuato, Mexico.
Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca, Chile.
Mol Cell Biochem. 2021 Mar;476(3):1555-1573. doi: 10.1007/s11010-020-04022-z. Epub 2021 Jan 4.
Far beyond the compelling proofs supporting that the metabolic syndrome represents a risk factor for diabetes and cardiovascular diseases, a growing body of evidence suggests that it is also a risk factor for different types of cancer. However, the involved molecular mechanisms underlying this association are not fully understood, and they have been mainly focused on the individual contributions of each component of the metabolic syndrome such as obesity, hyperglycemia, and high blood pressure to the development of cancer. The Receptor for Advanced Glycation End-products (RAGE) axis activation has emerged as an important contributor to the pathophysiology of many clinical entities, by fueling a chronic inflammatory milieu, and thus supporting an optimal microenvironment to promote tumor growth and progression. In the present review, we intend to highlight that RAGE axis activation is a crosswise element on the potential mechanistic contributions of some relevant components of metabolic syndrome into the association with cancer.
除了有力的证据表明代谢综合征是糖尿病和心血管疾病的一个风险因素之外，越来越多的证据表明，它也是不同类型癌症的一个风险因素。然而，这种关联背后的分子机制尚不完全清楚，主要集中在代谢综合征的各个组成部分（如肥胖、高血糖和高血压）对癌症发展的单独贡献上。晚期糖基化终产物（RAGE）轴的激活已成为许多临床实体病理生理学的一个重要贡献者，通过推动慢性炎症环境，从而为促进肿瘤生长和进展提供了最佳的微环境。在本综述中，我们旨在强调 RAGE 轴的激活是代谢综合征的一些相关成分与癌症相关的潜在机制贡献的一个交叉因素。
