来自蜘蛛黑腹漏斗蛛的麻痹性酰基多胺的结构。

Structures of paralytic acylpolyamines from the spider Agelenopsis aperta.

作者信息

Quistad G B, Suwanrumpha S, Jarema M A, Shapiro M J, Skinner W S, Jamieson G C, Lui A, Fu E W

机构信息

Sandoz Crop Protection Corporation, Palo Alto, California 94304.

出版信息

Biochem Biophys Res Commun. 1990 May 31;169(1):51-6. doi: 10.1016/0006-291x(90)91431-q.

DOI:10.1016/0006-291x(90)91431-q

PMID:2350352

Abstract

The structures are given for five paralytic acylpolyamines from the venom of the funnel web spider, Agelenopsis aperta. The acyl moieties are derived from (3-indolyl)acetic acid, (4-hydroxy-3-indolyl)acetic acid, and 4-hydroxybenzoic acid. The polyamine portions of the toxins are novel. Three toxins (AG489, AG505, and AG452) contain 1, 5, 9, 13, 18, 22-hexaazadocosane which is unique as a natural polyamine because of its length and hydroxylation at the 5-aza position. The polyamine portions of two other alpha-agatoxins (AG488 and AG504) are unusual also, containing guanidinooxy moieties.

摘要

给出了来自漏斗网蜘蛛（Agelenopsis aperta）毒液的五种麻痹性酰基多胺的结构。酰基部分衍生自（3-吲哚基）乙酸、（4-羟基-3-吲哚基）乙酸和4-羟基苯甲酸。毒素的多胺部分是新颖的。三种毒素（AG489、AG505和AG452）含有1,5,9,13,18,22-六氮杂二十二烷，由于其长度以及在5-氮杂位置的羟基化，它作为天然多胺是独特的。另外两种α-阿加毒素（AG488和AG504）的多胺部分也不寻常，含有胍基氧基部分。