Department of Biopathology and Hygiene of Animal and Food Productions, Section of Parasitology, Faculty of Veterinary Medicine, University of Perugia, San Costanzo 4 Street, Perugia, 06126, Italy.
Parasitol Res. 2013 Jun;112(6):2137-42. doi: 10.1007/s00436-013-3373-8. Epub 2013 Mar 16.
A blind, randomised, controlled, multicentric field trial was conducted to assess the influence of a metaphylactic treatment with an oral solution of toltrazuril on some reproductive parameters of Italian Fresian heifers during the first 18-20 months of life. For this goal 40 calves were selected from two dairy farms and randomly divided into two homogeneous groups: MTol, treated with toltrazuril and NegC, left untreated. The calves were clinically and coprologically examined over the entire study period. The body condition scores, the body weights and the age at the first service were recorded and compared between the two groups, in addition to some other reproductive parameters including number of pregnancies, average service per pregnancy, conception rate, conception rate at first service and post first service conception rate. The analysis of the results showed that the metaphylactic treatment with toltrazuril influenced positively the average age of the first service (MTol 461.4 days versus NegC 485.45 days), the overall conception rate (MTol 95 % versus NegC 85 %), the success at first (MTol 60 % versus NegC 45 %) and second (MTol 75 % versus NegC 45 %) services and, consequently, the mean number of services to be carried out for each animal (MTol 1.4 ± 0.6 versus NegC 1.6 ± 0.79). Furthermore, the results confirmed that toltrazuril treatment, applied in accordance with the epidemiological aspects of each farm, is highly efficacious in persistent reduction of oocyst excretions with particular reference to Eimeria zuernii, Eimeria bovis, considered to be mainly responsible for clinical coccidiosis.
一项盲法、随机、对照、多中心的田间试验旨在评估在意大利弗里斯奶牛生命的前 18-20 个月中,用托曲珠利口服液进行预防治疗对一些繁殖参数的影响。为此,从两个奶牛场选择了 40 头小牛,并随机分为两组:MTol 组用托曲珠利治疗,NegC 组未治疗。在整个研究期间对小牛进行临床和粪便检查。记录两组的体况评分、体重和首次配种年龄,并比较两组之间的其他一些繁殖参数,包括妊娠次数、每胎平均配种次数、受胎率、首次配种受胎率和首次配种后受胎率。结果分析表明,托曲珠利预防治疗对首次配种的平均年龄(MTol 461.4 天对 NegC 485.45 天)、总受胎率(MTol 95%对 NegC 85%)、首次配种的成功率(MTol 60%对 NegC 45%)和第二次配种的成功率(MTol 75%对 NegC 45%)有积极影响,从而使每头动物所需的配种次数平均减少(MTol 1.4±0.6 次对 NegC 1.6±0.79 次)。此外,结果证实,根据每个农场的流行病学情况,应用托曲珠利治疗对持续减少卵囊排泄非常有效,特别是对主要引起临床球虫病的艾美耳属球虫,如等孢球虫和牛艾美耳球虫。