Svensson C
Department of Animal Environment and Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Skara, Sweden.
Vet Parasitol. 1998 Jan 31;74(2-4):143-52. doi: 10.1016/s0304-4017(97)00154-4.
Twelve calves aged 6-10 months, and 12 calves aged 10-16 months were turned out onto a permanent pasture known to have been contaminated with oocysts of Eimeria alabamensis during the previous year. Two days after turnout, six of the older calves and six of the younger were each treated with one bolus per 200 kg bodyweight containing 1.6 g baquiloprim and 14.4 g sulphadimidine. The other 12 calves were left untreated. The excretion of Eimeria oocysts, the faecal dry matter and the weight gain of treated and untreated calves within each age group were compared during the first 3 weeks on pasture to assess the efficacy of the bolus in preventing E. alabamensis coccidiosis. All the older of the untreated calves and four of the younger developed gruel-like to watery diarrhoea 4-7 days after turnout. The faecal consistency of the treated calves remained firm and they lost significantly less weight than the control calves during the first 13 days on pasture. The treated calves also excreted significantly fewer oocysts during the first 20 days of grazing; their oocyst excretion remained low during days 8-10 when all but one of the diarrhoeic control calves excreted more than 850,000 oocysts per gram faeces (OPG). Starting on days 12 to 14 the oocyst excretion of 8 of the treated calves increased to 20,000-65,000 OPG and of 2 calves to 210,000-240,000 OPG. There was no difference in oocyst output between treated and untreated calves from the fourth week of grazing and no difference in weight gain among the younger calves. In the older calves there was a tendency for the untreated calves to gain more weight than treated calves.
将12头6至10个月大的小牛和12头10至16个月大的小牛放到一片已知在前一年被阿拉巴马艾美耳球虫卵囊污染的永久性牧场上。放牧两天后，6头年龄较大的小牛和6头年龄较小的小牛每200千克体重各用一粒含1.6克巴喹普明和14.4克磺胺二甲嘧啶的大丸剂进行治疗。另外12头小牛未接受治疗。在牧场放牧的前3周内，比较了各年龄组经治疗和未治疗小牛的艾美耳球虫卵囊排泄量、粪便干物质及体重增加情况，以评估大丸剂预防阿拉巴马艾美耳球虫病的效果。所有未治疗的年龄较大的小牛以及4头年龄较小的小牛在放牧4至7天后出现了稀粥样到水样腹泻。经治疗的小牛粪便质地保持坚实，并且在牧场放牧的前13天内体重减轻明显少于对照小牛。在放牧的前20天内，经治疗的小牛排出的卵囊也明显较少；在第8至10天，除一头腹泻的对照小牛外，所有对照小牛每克粪便中排出的卵囊超过850,000个时，经治疗小牛的卵囊排泄量仍很低。从第12至14天开始，8头经治疗小牛的卵囊排泄量增加到20,000 - 65,000个/克，2头小牛增加到210,000 - 240,000个/克。从放牧第四周起，经治疗和未治疗小牛的卵囊产量没有差异，年龄较小的小牛之间体重增加也没有差异。在年龄较大的小牛中，未治疗的小牛有比经治疗的小牛体重增加更多的趋势。
