Department of Mechanical Engineering , University of Colorado Denver, Campus Box 112, P.O. Box 173364, Denver, CO 80217-3364, USA.
Curr Osteoporos Rep. 2013 Jun;11(2):156-62. doi: 10.1007/s11914-013-0141-8.
Quantitative computed tomography (QCT) provides three-dimensional information about bone geometry and the spatial distribution of bone mineral. Images obtained with QCT can be used to create finite element models, which offer the ability to analyze bone strength and the distribution of mechanical stress and physical deformation. This approach can be used to investigate different mechanical loading scenarios (stance and fall configurations at the hip, for example) and to estimate whole bone strength and the relative mechanical contributions of the cortical and trabecular bone compartments. Finite element analyses based on QCT images of the hip and spine have been used to provide important insights into the biomechanical effects of factors such as age, sex, bone loss, pharmaceuticals, and mechanical loading at sites of high clinical importance. Thus, this analysis approach has become an important tool in the study of the etiology and treatment of osteoporosis at the hip and spine.
定量计算机断层扫描（QCT）提供了有关骨骼几何形状和骨矿物质空间分布的三维信息。使用 QCT 获得的图像可用于创建有限元模型，从而提供分析骨骼强度以及机械应力和物理变形分布的能力。这种方法可用于研究不同的机械加载情况（例如，髋关节的站立和跌倒姿势），并估计整个骨骼的强度以及皮质骨和松质骨腔室的相对机械贡献。基于髋关节和脊柱 QCT 图像的有限元分析已被用于深入了解年龄、性别、骨质流失、药物以及高临床重要部位机械加载等因素对生物力学的影响。因此，这种分析方法已成为研究髋部和脊柱骨质疏松症病因和治疗的重要工具。
