Lopez David, Kramer Christopher M
Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, VA.
Curr Cardiovasc Imaging Rep. 2013 Apr 1;6(2):150-157. doi: 10.1007/s12410-013-9191-7. Epub 2013 Jan 26.
Peripheral arterial disease (PAD) affects approximately 8 million Americans and is associated with high morbidity and increased mortality. Current therapies for PAD are limited and development of new therapeutic agents is needed. Present diagnostic methods for PAD are insensitive to the subtle microvascular and metabolic changes that occur beyond macrovacular stenosis and therefore may be less useful endpoints for clinical trials. Phosphorus-31 magnetic resonance (MR) spectroscopy, MR muscle perfusion, and MR oximetry are novel methods capable of evaluating both the macrovascular and microvascular changes that occur in PAD patients.
外周动脉疾病（PAD）影响着约800万美国人，与高发病率和死亡率增加相关。目前针对PAD的治疗方法有限，因此需要开发新的治疗药物。目前PAD的诊断方法对大血管狭窄之外发生的细微微血管和代谢变化不敏感，因此可能不太适用于临床试验的终点指标。磷-31磁共振（MR）波谱、MR肌肉灌注和MR血氧测定是能够评估PAD患者大血管和微血管变化的新方法。
