Universidad Nacional de Córdoba-Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Químicas, Departamento de Bioquímica Clínica-Centro de Investigaciones en Bioquímica Clínica e Inmunología, X5000HUA Córdoba, Argentina.
Int J Mol Sci. 2013 Mar 18;14(3):6170-86. doi: 10.3390/ijms14036170.
The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped into six subfamilies. The START domain containing 7 mRNA encodes StarD7, a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily, which was first identified as a gene overexpressed in a choriocarcinoma cell line. Recent studies show that the StarD7 protein facilitates the delivery of phosphatidylcholine to the mitochondria. This review summarizes the latest advances in StarD7 research, focusing on the structural and biochemical features, protein-lipid interactions, and mechanisms that regulate StarD7 expression. The implications of the role of StarD7 in cell proliferation, migration, and differentiation are also discussed.
类固醇生成急性调节蛋白（StAR）相关脂质转移（START）域蛋白构成了一个进化上保守且广泛表达的蛋白家族，它们与脂质转运、代谢和信号转导有关。15 种已充分研究的哺乳动物 START 结构域蛋白被分为六个亚家族。含 START 结构域的 7 号 mRNA 编码 StarD7，它是 StarD2/磷脂酰胆碱转移蛋白（PCTP）亚家族的成员，最初被鉴定为在绒毛膜癌细胞系中过度表达的基因。最近的研究表明，StarD7 蛋白有助于将磷脂酰胆碱递送到线粒体。本综述总结了 StarD7 研究的最新进展，重点介绍了结构和生化特征、蛋白-脂质相互作用以及调节 StarD7 表达的机制。还讨论了 StarD7 在细胞增殖、迁移和分化中的作用的意义。
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