Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT, USA.
Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT, USA.
Cell Metab. 2024 Sep 3;36(9):1963-1978. doi: 10.1016/j.cmet.2024.07.024. Epub 2024 Aug 22.
Oxidative phosphorylation (OXPHOS) occurs through and across the inner mitochondrial membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by lipid biosynthetic machinery localized in the IMM and class-specific lipid transporters that limit lipid traffic in and out of mitochondria. This unique lipid composition appears to be essential for functions of mitochondria, particularly OXPHOS, by its effects on direct lipid-to-protein interactions, membrane properties, and cristae ultrastructure. This review highlights the biological significance of mitochondrial lipids, with a particular spotlight on the role of lipids in mitochondrial bioenergetics. We describe pathways for the biosynthesis of mitochondrial lipids and provide evidence for their roles in physiology, their implications in human disease, and the mechanisms by which they regulate mitochondrial bioenergetics.
氧化磷酸化（OXPHOS）发生在线粒体的内外膜（IMM）上。线粒体膜含有独特的脂质组成，这得益于定位于 IMM 的脂质生物合成机制和特定于类别的脂质转运蛋白，它们限制了线粒体内外的脂质运输。这种独特的脂质组成似乎对线粒体的功能至关重要，特别是对氧化磷酸化，因为它直接影响脂质与蛋白质的相互作用、膜特性和嵴的超微结构。这篇综述强调了线粒体脂质的生物学意义，特别关注脂质在线粒体生物能量学中的作用。我们描述了线粒体脂质的生物合成途径，并提供了它们在生理学中的作用、在人类疾病中的意义以及它们调节线粒体生物能量学的机制的证据。
