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从 CX3CR1 角度看小胶质细胞。

Microglia, seen from the CX3CR1 angle.

机构信息

Department of Immunology, The Weizmann Institute of Science Rehovot, Israel.

出版信息

Front Cell Neurosci. 2013 Mar 18;7:26. doi: 10.3389/fncel.2013.00026. eCollection 2013.

DOI:10.3389/fncel.2013.00026
PMID:23507975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3600435/
Abstract

Microglial cells in brain and spinal cord are characterized by high expression of the chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane-tethered and sheddable chemokine CX3CL1/fractalkine, is restricted in the brain parenchyma to selected neurons. Here we summarize our current understanding of the physiological role of CX3CR1 for microglia function and the CX3C axis in microglial/neuronal crosstalk in homeostasis and under challenge. Moreover, we will discuss the efforts of our laboratory and others to exploit CX3CR1 promoter activity for the visualization and genetic manipulation of microglia to probe their functional contributions in the central nerve system (CNS) context.

摘要

脑和脊髓中的小胶质细胞的特征是趋化因子受体 CX3CR1 的高表达。唯一的 CX3CR1 配体，膜结合和可脱落的趋化因子 CX3CL1/fractalkine，在脑实质中的表达仅限于选定的神经元。在这里，我们总结了我们对 CX3CR1 对小胶质细胞功能的生理作用以及 CX3C 轴在稳态和挑战下小胶质细胞/神经元串扰中的理解。此外，我们还将讨论我们实验室和其他实验室为利用 CX3CR1 启动子活性进行小胶质细胞的可视化和遗传操作以探测它们在中枢神经系统 (CNS) 中的功能贡献所做的努力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4d6/3600435/33b192ff685a/fncel-07-00026-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4d6/3600435/601b83dd9025/fncel-07-00026-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4d6/3600435/a4fee6892b71/fncel-07-00026-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4d6/3600435/33b192ff685a/fncel-07-00026-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4d6/3600435/601b83dd9025/fncel-07-00026-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4d6/3600435/a4fee6892b71/fncel-07-00026-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4d6/3600435/33b192ff685a/fncel-07-00026-g0003.jpg

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本文引用的文献

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Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells.在炎症结肠中的 Ly6C hi 单核细胞产生促炎效应细胞和迁移性抗原呈递细胞。
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Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.
Haploinsufficiency at the CX3CR1 locus of hematopoietic stem cells favors the appearance of microglia-like cells in the central nervous system of transplant recipients.
造血干细胞 CX3CR1 基因座的单倍体不足有利于移植受者中枢神经系统中出现小胶质细胞样细胞。
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Microglia Signatures: A Cause or Consequence of Microglia-Related Brain Disorders?小胶质细胞特征：与小胶质细胞相关的脑疾病的原因还是结果？
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