Yuan S-M, Hong Z-J, Jiang H-Q, Wang J, Hu X-B
Department of Plastic Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China.
Phlebology. 2014 Apr;29(3):179-85. doi: 10.1177/0268355513477086. Epub 2013 May 6.
Complex venous malformations (VMs) may extensively involve the soft tissue. The treatment remains a challenge till now. Here we introduce a combinational therapy of copper wires and pingyangmycin (bleomycin A5,PYM).
Copper wires were retained in VMs by repeated penetration with a straight needle. Subsequently, PYM solution was injected into the lesion. Eight to 10 days later, copper wires were removed. The dressing was changed every day until the puncture pores healed. Magnetic resonance imaging scanning was performed to observe the change of VMs.
From January 2001 to December 2011, 56 patients were treated. During the follow-up period, most of the VMs shrunk obviously. The symptoms were relieved or disappeared. The complications included local pain, temporary paraesthesia and moderate fever, which disappeared quickly after the removal of copper wires.
This combinational therapy is a safe and effective approach for the complex VMs in soft tissue.
复杂静脉畸形（VMs）可广泛累及软组织。目前其治疗仍是一项挑战。在此我们介绍一种铜丝和平阳霉素（博来霉素A5，PYM）的联合治疗方法。
用直针反复穿刺将铜丝留置在静脉畸形内。随后，将平阳霉素溶液注入病变部位。8至10天后，取出铜丝。每天更换敷料直至穿刺孔愈合。进行磁共振成像扫描以观察静脉畸形的变化。
2001年1月至2011年12月，共治疗56例患者。在随访期间，大多数静脉畸形明显缩小。症状缓解或消失。并发症包括局部疼痛、暂时性感觉异常和中度发热，取出铜丝后很快消失。
这种联合治疗方法是治疗软组织复杂静脉畸形的一种安全有效的方法。
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