Jirková A
Oddĕleni patologie OUNZ, Tábor.
Cesk Patol. 1990 Mar;26(1):25-36.
Histochemical features of mucin were studied in a group of advanced cancers of the stomach. Study failed to find any essential difference in mucosubstances composition between diffuse type and intestinal type carcinomas. Proportion of single sulphated, non-sulphated and neutral components was always changing even in different parts of one tumour. An acid mucus with extracellular and intracellular admixture of O-acylsialomucin prevailed in 4 mucinous carcinomas similarly as in colorectal mucinous carcinomas. The study showed that single histologic types of carcinoma in different abdominal parts of digestive tract could not match in frequency but shared features of secretion without making any difference in localization. Occurrence of mixed tumours gives evidence of derivation of carcinomas from a common stem cell with various differentiang abilities.
对一组晚期胃癌的黏蛋白组织化学特征进行了研究。研究未能发现弥漫型和肠型癌在黏液物质组成上有任何本质区别。即使在同一肿瘤的不同部位,单硫酸化、非硫酸化和中性成分的比例也总是在变化。4例黏液腺癌中,与结直肠黏液腺癌一样,以含有细胞外和细胞内O-酰基唾液酸黏蛋白的酸性黏液为主。研究表明,消化道不同腹部部位的单一组织学类型癌在频率上并不匹配,但具有分泌特征,且在定位上没有任何差异。混合性肿瘤的出现证明了癌起源于具有不同分化能力的共同干细胞。