Pinto-de-Sousa João, David Leonor, Reis Celso A, Gomes Raquel, Silva Liliana, Pimenta Amadeu
Serviço de Cirurgia 4 Hospital S. João, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal.
Virchows Arch. 2002 Mar;440(3):304-10. doi: 10.1007/s00428-001-0548-y. Epub 2001 Oct 23.
Normal gastric mucosa expresses MUC1 and MUC5AC in foveolar epithelium and MUC6 in mucous neck cells of the body and deep glands of the antrum. Several studies have reported aberrant expression of an under-glycosylated form of MUC1, decreased expression of "gastric" mucins and aberrant expression of "non-gastric" mucins in gastric carcinoma. In this study, we analysed the expression profile of mucins MUC1, MUC2, MUC5AC and MUC6 in 94 gastric carcinomas using immunohistochemistry. Our results showed that: (1) mucin expression is associated with tumour type (MUC5AC with diffuse and infiltrative carcinomas and MUC2 with mucinous carcinomas) but not with the clinico-biological behaviour of the tumours; and (2) mucin expression is associated with tumour location (MUC5AC with antrum carcinomas and MUC2 with cardia carcinomas), indirectly reflecting differences in tumour differentiation according to tumour location.
正常胃黏膜在胃小凹上皮表达MUC1和MUC5AC，在胃体部和胃窦深部腺体的黏液颈细胞中表达MUC6。多项研究报道，胃癌中存在糖基化不足形式的MUC1异常表达、“胃型”黏蛋白表达降低以及“非胃型”黏蛋白异常表达。在本研究中，我们采用免疫组织化学方法分析了94例胃癌中黏蛋白MUC1、MUC2、MUC5AC和MUC6的表达谱。我们的结果显示：（1）黏蛋白表达与肿瘤类型相关（MUC5AC与弥漫浸润性癌相关，MUC2与黏液腺癌相关），但与肿瘤的临床生物学行为无关；（2）黏蛋白表达与肿瘤部位相关（MUC5AC与胃窦癌相关，MUC2与贲门癌相关），间接反映了根据肿瘤部位不同而存在的肿瘤分化差异。
