Swaney Paul, Thorp John, Allen Ian
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina.
Am J Perinatol. 2014 Feb;31(2):91-8. doi: 10.1055/s-0033-1338171. Epub 2013 Mar 18.
To assess the evidence available on the use of vitamin C supplementation greater than recommended dietary intake to reduce preterm birth rates.
Systematic review of randomized controlled trials using vitamin C alone or with one other supplement other than iron. Trials must report preterm birth rates but can have other primary outcomes. Preterm birth is defined as birth at less than 37 weeks' gestational age for this review. Review focused on studies with populations representative of Organization for Economic Co-operation and Development countries.
Inadequate level of evidence on the use of vitamin C alone to prevent preterm birth rates in low-risk populations based on one study. Three studies provided convincing evidence of no benefit in low-risk groups of use of vitamins C and E combined. Three studies provided adequate evidence of no benefit in high-risk groups of use of vitamins C and E combined.
The available evidence supports no benefit gained from using vitamin C to prevent preterm birth. Evidence does not support limiting use of vitamin C supplementation for other indications.
评估使用超过推荐膳食摄入量的维生素C补充剂以降低早产率的现有证据。
对单独使用维生素C或与除铁以外的其他一种补充剂联合使用的随机对照试验进行系统评价。试验必须报告早产率，但可以有其他主要结局。本次评价中早产定义为妊娠小于37周分娩。评价重点关注具有经济合作与发展组织国家代表性人群的研究。
基于一项研究，单独使用维生素C预防低风险人群早产率的证据不足。三项研究提供了令人信服的证据，表明联合使用维生素C和E对低风险组无益处。三项研究提供了充分的证据，表明联合使用维生素C和E对高风险组无益处。
现有证据支持使用维生素C预防早产无益处。证据不支持因其他适应证而限制维生素C补充剂的使用。
